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Newsletter: Dr Nocchi and Dr Daly using ShARM

Welcome to the July edition of our newsletter! We will bring you updates on the facility, relevant news and information and details of upcoming meetings.

Profiles: Dr Linda Nocchi and Dr Donna Daly on using ShARM tissues in their paper for Aging Cell

Publication of your findings is a marker of success for any researcher, so it is with great honour that we can announce that the first publication, using tissues acquired through ShARM has been published in Aging Cell.

Dr Linda Nocchi and Dr Donna Daly are co-authors of ”Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging” (Nocchi et al, 2014).  For their paper, Drs Nocchi and Daly used bladders, collected on spec in RNAlater by ShARM and they have agreed to tell us about their experience of supporting ShARM.

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Dr Daly tells us: “I first heard ShARM mentioned in the lab, but had no experience with them until I met Adele, the ShARM coordinator, at a conference. I was planning a harvest from my own aged mice and had already coordinated a network of people to collect the tissues I didn’t need. I actively support any 3R activity and although it was challenging to coordinate I was able to provide tissues for 4 projects, in addition to my own. I think its important to get the most out of each mouse so I was pleased that ShARM was able to collect the remaining tissues, and the process was easy enough. It’s a shame that sharing isn’t more commonplace, it should be mandatory and written into funding contracts similar to the NIA. But it is difficult so I can understand why it isn’t done more.”

After donating tissue, we decided to try using some tissues from the biorepository. Tissue quality was a concern but ShARM are able to exchange any problematic tissues, and the price of the individual tissues meant it was a low risk trial, worth exploring as in the future, quick easy access to tissues would help reduce costs and increase the turnaround time of projects. The tissues performed as expected and since our first set of tissues, we have had additional tissues from ShARM, as well as young control tissues which is really useful to maintain consistency in conditions such as housing etc.

Publishing this paper would have been challenging without the tissues from ShARM, and having donated tissues, we are able to include this as a collaborative/ethical action in future funding applications, to demonstrate dedication to the 3R’s.

You can read more about the work undertaken by Dr Daly in the Grundy lab here and their paper is available here

Nocchi, L., Daly, D. M., Chapple, C., & Grundy, D. (2014). Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging. Aging cell, 13(3), 540-550.

Flash Frozen and Wax Embedded Tissues Currently Available

The following tissues are currently available for immediate purchase, either flash frozen or as wax blocks. Tissues are priced at £35 for aged tissue and £30 for young controls (+ VAT and shipping costs). Email info@ShARMUK.org for more details.

Strains

 

Age range

Tissues Available

C57BL/6J
C57BL/6JBabr
C57BL/6N
C57BL/Icrfat

 

1 - 4 months 
and
13 - 33 months

Bladder
Bone (femur, tibia, vertebra)
Brain
Brown adipose tissue
Eyes
Intestine (duodenum, jejunum, ileum, cecum, colon)
Heart
Kidney
Liver (median, left, right and caudate lobes)
Lung
Mammary fat pad
Muscle
Pancreas
Prostate
Skin
Spleen
Thymus
Thyroid
White adipose tissue

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Upcoming harvests

We are anticipating the harvest of male, C57BL/6JBabr mice aged 22 - 23 months. If you would be interested in any tissues not already available, please send your request to info@ShARMUK.org

Upcoming meetings

Please see details of upcoming meetings which may be of interest

Year  

Month

Days

Event

City

2014

   July

16 - 17

8th Annual A5M Anti-Ageing & Aestetic
Medicine Conference: Stress and Ageing - Taking Theory to Practice

Melbourne, Australia
 

2014

   July

06 - 11

Genomic Instability - Mechanisms that cause DNA Damage and related Diseases

Hong Kong,
China
 

2014

   July

01 - 04

Universitas 21 Graduate Research Conference: Celebrating Ageing Research

Auckland,
New Zealand
 

2014

   August

26 - 28

Healthy and Active Aging Conference (HAAC 2014)

Suzhou,
China
 

2014

 September

12 - 14

New Zealand Association of Gerontology Conference

Dunedin,
New Zealand
 

2014

 September

8-9

Workshop - Systems Biology of Ageing

Jena,
Germany
 

2014

 September

2-5

International Study Group for Systems Biology (ISGSB) meeting 2014: From Cell to Organism

Durham,
UK
 

2014

 September

19-22

Biology of Human Aging Conference 2014

Oropesa,
Spain
 

2014

   October

16-18

43rd Annual Scientific and Educational Meeting of the Canadian Association on Gerontology (CAG2014.CA)

Ontario,
Canada
 

2014

   October

16-18

9th European Congress of Biogerontology

Seville,
Spain
 

2014

   October

9-11

62nd Annual & Scientific Meeting 2014 of the Irish Gerontological Society (IGS)

Galway,
Ireland
 

2014

   November

17-19

World Congress of Gerontology and Geriatrics / 3rd International Conference on Healthy Ageing in the Changing World

Bengaluru,
India
 

2014

   November

1-2

International Conference on Aging and Disease 2014

Beijing,
China
 

2014

   November

17-20

Frontiers in Metabolism: From Molecular Physiology to Systems Medicine (Symposium)

Heidelberg, Germany
 

2015

   April

23-26

International Association of Gerontology and Geriatrics for the European Region (IAGG-ER) VIII Congress

Dublin,
Ireland
 

2015

  July

27-29

2nd World Congress on Healthy Ageing

Johannesburg, South Africa
 

Have your say

These newsletters are designed to bring you interesting and relevant information. Please email us if you would like to contribute information, ask a question, promote relevant work or opportunities or have any other suggestions for content.

 

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